Dermal fibroblasts exhibit considerable heterogeneity during homeostasis and in response
to injury. Defining lineage origins of reparative fibroblasts and regulatory programs that drive …

Split-thickness skin grafting is the most common reconstructive procedure in managing burn
injuries. Harvesting split-thickness skin creates a new partial thickness wound referred to as …

How distinct transcriptional programs are enacted to generate cellular heterogeneity and
plasticity, and enable complex fate decisions are important open questions. One key regulator …

Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and
disease by producing complex extracellular matrix and creating signaling niches through …

The mammalian hair follicle undergoes repeated bouts of regeneration orchestrated by a
variety of hair follicle stem cells. The last decade has witnessed the emergence of the immune …

Although critical for host defense, innate immune cells are also pathologic drivers of acute
respiratory distress syndrome (ARDS). Innate immune dynamics during Coronavirus Disease …

B cell maturation antigen (BCMA) target loss is considered to be a rare event that mediates
multiple myeloma (MM) resistance to anti-BCMA chimeric antigen receptor T cell (CAR T) or …

Adult mammalian skin wounds heal by forming fibrotic scars. We report that full-thickness
injuries of reindeer antler skin (velvet) regenerate, whereas back skin forms fibrotic scar. Single-…

Pro-regenerative macrophages are well known for their role in promoting tissue repair;
however, their specific roles in promoting regeneration of the injured nerve are not well defined. …

Microglia and infiltrating macrophages are thought to orchestrate the central nervous system
(CNS) response to injury; however, the similarities between these cells make it challenging …