Inhibition of apoptosis signal–regulating kinase 1, a serine/threonine kinase, leads to
improvement in inflammation and fibrosis in animal models of nonalcoholic steatohepatitis. We …

Background and Aims We evaluated the safety and efficacy of cilofexor (formerly GS‐9674),
a small‐molecule nonsteroidal agonist of farnesoid X receptor, in patients with nonalcoholic …

Background & Aims This study’s aim was to assess the histological and metabolic effects of
n-3 polyunsaturated fatty acids (PUFAs) vs. placebo while adjusting for the impact of age and …

Background & Aims Non-invasive tools for monitoring treatment response and disease
progression in non-alcoholic steatohepatitis (NASH) are needed. Our objective was to evaluate …

OBJECTIVES: Screening tools to determine which outpatients with cirrhosis are at highest
risk forunplannedhospitalization are lacking. Frailty is a novel prognostic factor but …

Mycophenolate mofetil (MMF) is a commonly used immunosuppressive drug used in the
management of transplant recipients. Although gastrointestinal (GI) toxicity is a known …

The majority of patients on a waiting list for liver transplantation have end‐stage liver disease.
Because of the marked peripheral vasodilatation of end‐stage cirrhosis that masks a latent …

Background & Aims Antibiotics frequently are overused and are associated with serious
adverse events in patients with cirrhosis. However, these drugs are recommended for all …

Purpose In obesity and diabetes the liver is highly susceptible to abnormal uptake and
storage of fat. In certain individuals hepatic steatosis predisposes to the development of non-…

Background Nonalcoholic fatty liver disease (NAFLD) is a prevalent disorder associated
with obesity and diabetes. Few treatment options are effective for patients with NAFLD, but …