[BOOK][B] Bayesian adaptive methods for clinical trials
Already popular in the analysis of medical device trials, adaptive Bayesian designs are
increasingly being used in drug development for a wide variety of diseases and conditions, from …
increasingly being used in drug development for a wide variety of diseases and conditions, from …
Effect of hydrocortisone on mortality and organ support in patients with severe COVID-19: the REMAP-CAP COVID-19 corticosteroid domain randomized clinical trial
Importance Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19)
is limited. Objective To determine whether hydrocortisone improves outcome for …
is limited. Objective To determine whether hydrocortisone improves outcome for …
Comparison of antiarrhythmic drug therapy and radiofrequency catheter ablation in patients with paroxysmal atrial fibrillation: a randomized controlled trial
…, MR Reynolds, C Vinekar, CY Liu, SM Berry, DA Berry… - Jama, 2010 - jamanetwork.com
Context Antiarrhythmic drugs are commonly used for prevention of recurrent atrial fibrillation
(AF) despite inconsistent efficacy and frequent adverse effects. Catheter ablation has been …
(AF) despite inconsistent efficacy and frequent adverse effects. Catheter ablation has been …
Association between administration of IL-6 antagonists and mortality among patients hospitalized for COVID-19: a meta-analysis
Importance Clinical trials assessing the efficacy of IL-6 antagonists in patients hospitalized
for COVID-19 have variously reported benefit, no effect, and harm. Objective To estimate the …
for COVID-19 have variously reported benefit, no effect, and harm. Objective To estimate the …
[HTML][HTML] Cetuximab for the treatment of colorectal cancer
…, JR Zalcberg, D Tu, HJ Au, SR Berry… - … England Journal of …, 2007 - Mass Medical Soc
Background Cetuximab, an IgG1 chimeric monoclonal antibody against epidermal growth
factor receptor (EGFR), has activity against colorectal cancers that express EGFR. Methods …
factor receptor (EGFR), has activity against colorectal cancers that express EGFR. Methods …
A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer's disease
Dominantly inherited Alzheimer’s disease (DIAD) causes predictable biological changes
decades before the onset of clinical symptoms, enabling testing of interventions in the …
decades before the onset of clinical symptoms, enabling testing of interventions in the …
Derivation, validation, and potential treatment implications of novel clinical phenotypes for sepsis
Importance Sepsis is a heterogeneous syndrome. Identification of distinct clinical phenotypes
may allow more precise therapy and improve care. Objective To derive sepsis phenotypes …
may allow more precise therapy and improve care. Objective To derive sepsis phenotypes …
Classification and pathophysiology of enterocutaneous fistulas
SM Berry, JE Fischer - Surgical Clinics, 1996 - surgical.theclinics.com
Many classification schemes have been used to define fistulas of the gastrointestinal (GI) tract.
Anatomic, physiologic, and etiologic classification schemes are the most commonly used. …
Anatomic, physiologic, and etiologic classification schemes are the most commonly used. …
Interleukin-6 receptor antagonists in critically ill patients with Covid-19–preliminary report
Background The efficacy of interleukin-6 receptor antagonists in critically ill patients with
coronavirus disease 2019 (Covid-19) is unclear. Methods We evaluated tocilizumab and …
coronavirus disease 2019 (Covid-19) is unclear. Methods We evaluated tocilizumab and …
[HTML][HTML] A minimal common outcome measure set for COVID-19 clinical research
Clinical research is necessary for an effective response to an emerging infectious disease
outbreak. However, research efforts are often hastily organised and done using various …
outbreak. However, research efforts are often hastily organised and done using various …