… Tahira Devji, Ydo Kleinlugtenbelt and Shoghag Khoudigian conducted the risk-of-bias and
methodologic assessments. Tahira Devji and Shoghag Khoudigian conducted the statistical …

Background Surrogate outcomes are a significant challenge in drug evaluation for health
technology assessment (HTA) agencies. The research objectives were to: identify factors …

Lorlatinib is the only targeted therapy approved in Canada to treat patients with anaplastic
lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) whose tumor has …

Background Several treatments for plaque psoriasis are available, but it remains challenging
for physicians to make informed treatment decisions due to a lack of head-to-head trials. …

Aim: There is growing interest in novel insulin management systems that improve glycemic
control. This study aimed to evaluate the cost–effectiveness of smart connected insulin re-…

Introduction COPD places a huge clinical and economic burden on the US health care
system, with acute exacerbations representing a key driver of direct medical costs. Current …

Introduction Approximately half of oral cancers are detected in advanced stages. The current
gold standard is histopathological assessment of biopsied tissue, which is subjective and …

METHODS Patient charts from Medical, General Surgical, Neurosurgical and Trauma
services admitted to the ICU at the Hamilton General Hospital were retrospectively audited to …

… The contributions of Shoghag Khoudigian-Sinani to all of the papers in this thesis include:
developing the research ideas and research questions, collecting the required data, …

Objectives: Early cost-effectiveness analysis (CEA) is becoming an attractive approach to
inform manufacturers whether to continue investing resources into developing the device and …