Recent research has demonstrated that the non-coding genome plays a key role in genetic
programming and gene regulation during development as well as in health and …

One early phase of atherosclerosis involves the recruitment of inflammatory cells from the
circulation and their transendothelial migration. This process is predominantly mediated by …

Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …

Background Variability of gene expression in human may link gene sequence variability and
phenotypes; however, non-genetic variations, alone or in combination with genetics, may …

Background Cardiac troponin testing is central to the diagnosis of acute myocardial infarction.
We evaluated a sensitive troponin I assay for the early diagnosis and risk stratification of …

Background— Matrix metalloproteinase (MMP)-9 secretion by macrophages and other
inflammatory cells accelerates atherosclerotic progression and destabilizes vulnerable plaque in …

Background Cellular antioxidant enzymes such as glutathione peroxidase 1 and superoxide
dismutase have a central role in the control of reactive oxygen species. In vitro data and …

Genome-wide association studies have identified numerous loci linked with complex diseases,
for which the molecular mechanisms remain largely unclear. Comprehensive molecular …

Heart failure is a consequence of various cardiovascular diseases and associated with poor
prognosis. Despite progress in the treatment of heart failure in the past decades, prevalence …

Background Modern genotyping platforms permit a systematic search for inherited components
of complex diseases. We performed a joint analysis of two genomewide association …