Background The recurrence score based on the 21-gene breast-cancer assay has been
clinically useful in predicting a chemotherapy benefit in hormone-receptor–positive, human …

Purpose The standard of care for second-line therapy in patients with advanced pancreatic
cancer after gemcitabine-based therapy is not clearly defined. The CONKO-003 phase III …

Purpose: To make recommendations regarding the use of bisphosphonates and other bone-modifying
agents as adjuvant therapy for patients with breast cancer. Methods: Cancer Care …

• All visits should include a medical history. For women who are taking tamoxifen, it is important
to ask about vaginal bleeding. Physical examination should include breasts, regional …

Purpose To update, in collaboration with Cancer Care Ontario (CCO), key recommendations
of the American Society of Clinical Oncology (ASCO) guideline on the role of bone-…

PURPOSE To update recommendations of the American Society of Clinical Oncology (ASCO)-Ontario
Health (Cancer Care Ontario [CCO]) adjuvant bone-modifying agents in breast …

Objectives This study sought to evaluate the safety of continuing trastuzumab in patients
with human epidermal growth factor receptor–positive breast cancer who developed mild …

Background Natural killer (NK) cells play a critical role in cancer immunosurveillance.
Recent developments in NK cell ex-vivo expansion makes it possible to generate millions of …

Background Preclinical evidence suggests statins may have anti-tumor properties. Large
observational studies are also consistent with improved survival and cancer-specific outcomes …

Background Human epidermal growth factor receptor 2 (HER2) overexpressing malignancies,
including breast and gastro-esophageal, are associated with a poor prognosis. The …