Neuronal loss in Parkinson’s disease (PD) is associated with aberrant mitochondrial function
and impaired proteostasis. Identifying the mechanisms that link these pathologies is critical …

Fibro-adipogenic progenitors (FAPs) are important components of the skeletal muscle
regenerative environment. Whether FAPs support muscle regeneration or promote fibro-…

Neuronal loss in Parkinson's disease (PD) is associated with impaired proteostasis and
accumulation of α-syn microaggregates in dopaminergic neurons. These microaggregates …

Neuronal loss in Parkinson's disease (PD) is associated with aberrant mitochondrial function
in dopaminergic (DA) neurons of the substantia nigra pars compacta. An association has …

Human embryonic stem cells (hESCs) are a potential source of material for cell therapy of
muscle diseases. To date, it has proven difficult to generate skeletal muscle from hESCs in …

The Sonic Hedgehog (Shh) signaling pathway is important for neurogenesis in vivo. Gli
transcription factors, effector proteins of the Shh signaling pathway, have neurogenic properties …

While mutations in the SNCA gene (α-synuclein [α-syn]) are causal in rare familial forms of
Parkinson’s disease (PD), the prevalence of α-syn aggregates in the cortices of sporadic …

Objectives The authors aimed to identify risk factors and outcomes associated with new-onset
atrial fibrillation (NOAF) after transcatheter aortic valve replacement (TAVR). Background …

Children's literature is a primary source for introducing young children to new words at
home and at school, and children's early vocabulary knowledge is a key component of oral …

10.7554/eLife.12534.001 Change in the identity of the components of the transcription pre-initiation
complex is proposed to control cell type-specific gene expression. Replacement of …