Immune checkpoint inhibitors, which unleash a patient’s own T cells to kill tumors, are
revolutionizing cancer treatment. To unravel the genomic determinants of response to this therapy, …

Background Immune checkpoint inhibitors are effective cancer treatments, but molecular
determinants of clinical benefit are unknown. Ipilimumab and tremelimumab are antibodies …

Cardiovascular disease (CVD) is the leading cause of mortality in women. In fact, CVD is
responsible for a third of all deaths of women worldwide and half of all deaths of women over …

Activation of the ATR kinase following perturbations to DNA replication relies on a complex
mechanism involving ATR recruitment to RPA-coated single-stranded DNA via its binding …

p53 is primarily known as a downstream transcriptional effector in the DNA damage-response
cascade. We report that endogenous p53 rapidly accumulates at DNA damage sites …

Background and Purpose. The Bobath neurodevelopmental treatment approach advised
against the use of resistive exercise, as proponents felt that increased effort would increase …

There is no need for further studies to show that severely malnourished children are at
greater risk of dying than healthy children. There is a pressing need, on the other hand, for …

The sensitivity of the pendulum test to variation in spasticity in persons with spastic cerebral
palsy (CP) was tested in 30 participants with CP and 10 participants without CP (controls) (…

It has been four decades since the discovery of p53, the designated ‘Guardian of the Genome’.
P53 is primarily known as a master transcription factor and critical tumor suppressor, with …

The effect of increased hydrophobicity at position 6 of luteinizing hormone-releasing hormone
(LH-RH) has been investigated by the incorporation of a series of 15 very hydrophobic, …