In The Historic Turn in the Human Sciences eleven scholars widely known for their interdisciplinary
work investigate one of the most striking developments in the intellectual world today: …

Neuromedin U (NMU) is a neuropeptide with potent activity on smooth muscle which was
isolated first from porcine spinal cord and later from other species 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 . It is …

The two mammalian neuropeptides NPFF and NPAF have been shown to have important
roles in nociception, anxiety, learning and memory, and cardiovascular reflex. Two receptors (…

Parkinson's disease (PD) is a debilitating movement disorder that afflicts >1 million people in
North America. Current treatments focused on dopamine-replacement strategies ultimately …

Melanin-concentrating hormone (MCH) is a 19-aa cyclic neuropeptide originally isolated
from chum salmon pituitaries. Besides its effects on the aggregation of melanophores in fish …

Urotensin II (UII) is a neuropeptide with potent cardiovascular effects. Its sequence is
strongly conserved among different species and has structural similarity to somatostatin. No …

We have isolated and determined the coding sequences of human and mouse orthologs of
the rat orphan G-protein-coupled receptor GPR54. Mouse and rat GPR54 are nearly 95% …

Narcolepsy type 1 (NT1) is a chronic neurological disorder that impairs the brain’s ability to
control sleep-wake cycles. Current therapies are limited to the management of symptoms …

Current treatments for insomnia, such as zolpidem (Ambien) and eszopiclone (Lunesta), are
γ-aminobutyric acid type A (GABA A )–positive allosteric modulators that carry a number of …

Background Drugs targeting insomnia ideally promote sleep throughout the night, maintain
normal sleep architecture, and are devoid of residual effects associated with morning …