User profiles for Theo J. Moraes

Theo Moraes

SickKids, Toronto
Verified email at sickkids.ca
Cited by 9090

[PDF][PDF] Composition and variation of the human milk microbiota are influenced by maternal and early-life factors

…, PJ Mandhane, SE Turvey, P Subbarao, TJ Moraes… - Cell host & …, 2019 - cell.com
Breastmilk contains a complex community of bacteria that may help seed the infant gut
microbiota. The composition and determinants of milk microbiota are poorly understood. Among …

Identification of nucleolin as a cellular receptor for human respiratory syncytial virus

F Tayyari, D Marchant, TJ Moraes, W Duan… - Nature medicine, 2011 - nature.com
Human respiratory syncytial virus (RSV) causes a large burden of disease worldwide 1 .
There is no effective vaccine or therapy, and the use of passive immunoprophylaxis with RSV-…

[HTML][HTML] Screen-time is associated with inattention problems in preschoolers: Results from the CHILD birth cohort study

…, J Chikuma, DL Lefebvre, MB Azad, TJ Moraes… - PloS one, 2019 - journals.plos.org
Background Pre-school children spend an average of two-hours daily using screens. We
examined associations between screen-time on pre-school behavior using data from the …

[PDF][PDF] Breastmilk feeding practices are associated with the co-occurrence of bacteria in mothers' milk and the infant gut: the CHILD cohort study

…, PJ Mandhane, MR Sears, E Khafipour, TJ Moraes… - Cell host & …, 2020 - cell.com
Gut microbiota play a critical role in infant health. It is now accepted that breastmilk contains
live bacteria from endogenous and exogenous sources, but it remains unclear whether …

A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity

DJ Marchant, CL Bellac, TJ Moraes, SJ Wadsworth… - Nature medicine, 2014 - nature.com
Interferon-α (IFN-α) is essential for antiviral immunity, but in the absence of matrix
metalloproteinase-12 (MMP-12) or IκBα (encoded by NFKBIA) we show that IFN-α is retained in the …

Decreasing antibiotic use, the gut microbiota, and asthma incidence in children: evidence from population-based and prospective cohort studies

…, AB Becker, PJ Mandhane, TJ Moraes… - The Lancet …, 2020 - thelancet.com
Background Childhood asthma incidence is decreasing in some parts of Europe and North
America. Antibiotic use in infancy has been associated with increased asthma risk. In the …

Association of exposure to formula in the hospital and subsequent infant feeding practices with gut microbiota and risk of overweight in the first year of life

…, PJ Mandhane, SE Turvey, TJ Moraes… - JAMA …, 2018 - jamanetwork.com
Importance The effect of neonatal and infant feeding practices on childhood obesity is unclear.
The gut microbiome is strongly influenced by feeding practices and has been linked to …

Neutrophil granule contents in the pathogenesis of lung injury

TJ Moraes, JH Zurawska… - Current opinion in …, 2006 - journals.lww.com
The primary function of neutrophils in the innate immune response–to contain and kill invading
microbial pathogens–is achieved through a series of rapid and coordinated responses …

[HTML][HTML] 'Human Milk Oligosaccharide Concentrations Are Associated with Multiple Fixed and Modifiable Maternal Characteristics, Environmental Factors, and …

…, F Atakora, AB Becker, P Subbarao, TJ Moraes… - The Journal of …, 2018 - Elsevier
Background Human milk oligosaccharides (HMOs) shape the developing gut microbiome
and influence immune function. Aside from genetic Secretor status, the factors influencing …

Infant feeding and weight gain: separating breast milk from breastfeeding and formula from food

…, AB Becker, PJ Mandhane, SE Turvey, TJ Moraes… - …, 2018 - publications.aap.org
OBJECTIVES: Studies addressing breastfeeding and obesity rarely document the method of
breast milk feeding, type of supplementation, or feeding in hospital. We investigated these …