Peripheral blood γ‐δ T cells lyse fresh human brain—Derived oligodendrocytes

MS Freedman, TCG Ruijs, LK Selin… - Annals of …, 1991 - Wiley Online Library
T cells are postulated to contribute to the injury of the oligodendrocyte‐myelin complex
underlying the demyelinating disease multiple sclerosis (MS). The apparent lack of class I or II …

Immunohistochemical studies of adult human glial cells

Y Grenier, TCG Ruijs, Y Robitaille, A Olivier… - Journal of …, 1989 - Elsevier
Using immunohistochemical techniques, we examined major histocompatibility complex (MHC)
antigen expression on astrocytes, oligodendrocytes, and macrophages-microglia …

A regional massive hemorrhage protocol developed through a modified Delphi technique

…, W Owens, M Pai, S Rizoli, T Ruijs… - … Open Access Journal, 2019 - cmajopen.ca
Background: A massive hemorrhage protocol (MHP) enables rapid delivery of blood components
in a patient who is exsanguinating pending definitive hemorrhage control, but there is …

Human oligodendrocytes are susceptible to cytolysis by major histocompatibility complex class I-restricted lymphocytes

TCG Ruijs, MS Freedman, YG Grenier, A Olivier… - Journal of …, 1990 - Elsevier
The majority of human oligodendrocytes in enriched glial cell cultures expresses class I major
histocompatibility complex (MHC) antigens. We used a 51 Cr release assay to study the …

Differential expression of heat shock proteins by human glial cells

MS Freedman, NN Buu, TCJ Ruijs, K Williams… - Journal of …, 1992 - Elsevier
Heat shock proteins (HSP) have been implicated in the interactions between the γδ T
lymphocyte population and target tissues. γδ T cells are found in increased numbers in multiple …

Phenotypic and functional characteristics of activated CD8+ cells: a CD11b− CD28− subset mediates noncytolytic functional suppression

MS Freedman, TCG Ruijs, M Blain, JP Antel - Clinical immunology and …, 1991 - Elsevier
Freshly isolated human CD8 + cells can be divided into mutually exclusive subsets bearing
the phenotypes CD11b + (CD28 − ) or CD28 + (CD11b − ). We found that activation of CD8 + …

Expression and modulation of HLA-DR on cultured human adult astrocytes

VW Yong, FP Yong, TCG Ruijs… - … of Neuropathology & …, 1991 - academic.oup.com
Expression of Class II major histocompatibility complex (MHQ antigens on astrocytes has been
implicated as contributing to the immune responses characteristic of chronic autoimmune …

A prospective multi‐faceted interventional study of blood bank technologist screening of red blood cell transfusion orders: The START study

…, M Angers, N Pilutti, R Lett, S Dowsley, T Ruijs… - …, 2021 - Wiley Online Library
Background Transfusion of red blood cells (RBC) is a common procedure, which when
prescribed inappropriately can result in adverse patient outcomes. This study sought to …

Serum cytotoxicity to human and rat oligodendrocytes in culture

TCG Ruijs, A Olivier, JP Antel - Brain Research, 1990 - Elsevier
Serum from multiple sclerosis (MS) patients can cause demyelination in rat CNS explant
cultures and induce cytotoxicity to rat oligodendrocytes in culture. The interpretation of these …

Intravenous albumin utilization audit at a large community hospital

R Jug, J Callum, T Ruijs, Y Liu, R Barty… - Transfusion, 2024 - Wiley Online Library
Background There is a literature gap in terms of albumin utilization practices. Methods/Materials
We conducted a single‐center retrospective observational electronic audit of adult …