Background There is substantial variability in the perioperative administration of aspirin in
patients undergoing noncardiac surgery, both among patients who are already on an aspirin …

Background Perioperative bleeding is common in patients undergoing noncardiac surgery.
Tranexamic acid is an antifibrinolytic drug that may safely decrease such bleeding. Methods …

Background Marked activation of the sympathetic nervous system occurs during and after
noncardiac surgery. Low-dose clonidine, which blunts central sympathetic outflow, may …

Importance Acute kidney injury, a common complication of surgery, is associated with poor
outcomes and high health care costs. Some studies suggest aspirin or clonidine …

Background Myocardial injury after non-cardiac surgery (MINS) increases the risk of
cardiovascular events and deaths, which anticoagulation therapy could prevent. Dabigatran …

Background We aimed to establish diagnostic criteria for bleeding independently associated
with mortality after noncardiac surgery (BIMS) defined as bleeding during or within 30 days …

Background For patients undergoing noncardiac surgery, bleeding and hypotension are
frequent and associated with increased mortality and cardiovascular complications. Tranexamic …

Background: Remote ischemic preconditioning is a simple therapy that may reduce cardiac
and kidney injury. We undertook a randomized controlled trial to evaluate the effect of this …

Importance Although major bleeding is among the most common and prognostically important
perioperative complications, the relative timing of bleeding events is not well established. …

Background Cardiac surgery patients are at high risk for postoperative bleeding. Intravenous
(IV) tranexamic acid (TxA) is a commonly used antifibrinolytic drug, but is associated with …