Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension: comparison with inhaled nitric oxide

E Michelakis, W Tymchak, D Lien, L Webster… - Circulation, 2002 - Am Heart Assoc
Background— The prognosis of patients with severe pulmonary hypertension (PHT) is poor.
To determine prognosis and guide therapy, an acute hemodynamic trial of selective …

Long-term treatment with oral sildenafil is safe and improves functional capacity and hemodynamics in patients with pulmonary arterial hypertension

ED Michelakis, W Tymchak, M Noga, L Webster… - Circulation, 2003 - Am Heart Assoc
Background— The prognosis and functional capacity of patients with pulmonary arterial
hypertension (PAH) is poor, and there is a need for safe, effective, inexpensive oral treatments. …

Noninvasive risk assessment early after a myocardial infarction: the REFINE study

…, S Gulamhussein, J McMeekin, W Tymchak… - Journal of the American …, 2007 - jacc.org
Objectives : This study sought to determine whether combined assessment of autonomic
tone plus cardiac electrical substrate identifies most patients at risk of serious events after …

Epidemiology of shock in contemporary cardiac intensive care units: data from the critical care cardiology trials network registry

…, MA Solomon, B Ternus, W Tymchak… - … Quality and Outcomes, 2019 - Am Heart Assoc
Background Clinical investigations of shock in cardiac intensive care units (CICUs) have
primarily focused on acute myocardial infarction (AMI) complicated by cardiogenic shock (…

Long-term effects of cholesterol lowering and angiotensin-converting enzyme inhibition on coronary atherosclerosis: The Simvastatin/Enalapril Coronary …

…, CE Buller, S Plante, D Catellier, W Tymchak… - Circulation, 2000 - Am Heart Assoc
Background—This long-term, multicenter, randomized, double-blind, placebo-controlled, 2×2
factorial, angiographic trial evaluated the effects of cholesterol lowering and angiotensin-…

2-year follow-up of patients undergoing transcatheter aortic valve implantation using a self-expanding valve prosthesis

…, M Labinaz, P den Heijer, M Mullen, W Tymchak… - Journal of the American …, 2011 - jacc.org
Objectives : The purpose of this study was to evaluate the safety, device performance, and
clinical outcome up to 2 years for patients undergoing transcatheter aortic valve implantation (…

Management and outcomes of cardiogenic shock in cardiac ICUs with versus without shock teams

…, JR Snell, SS Sinha, WJ Tymchak… - Journal of the American …, 2021 - jacc.org
Background Single-center studies suggest that implementation of multidisciplinary cardiogenic
shock (CS) teams is associated with improved CS survival. Objectives The aim was to …

Demographics, care patterns, and outcomes of patients admitted to cardiac intensive care units: the Critical Care Cardiology Trials Network Prospective North …

…, RJ Snell, MA Solomon, B Ternus, W Tymchak… - JAMA …, 2019 - jamanetwork.com
Importance Single-center and claims-based studies have described substantial changes in
the landscape of care in the cardiac intensive care unit (CICU). Professional societies have …

Effects of aerobic or aerobic and resistance training on cardiorespiratory and skeletal muscle function in heart failure: a randomized controlled pilot trial

S Mandic, W Tymchak, D Kim, B Daub… - Clinical …, 2009 - journals.sagepub.com
Objective: To examined the effects of different training modalities on exercise capacity (Vo
2peak ), systolic function, muscular strength and endurance and quality of life in heart failure …

Role of vascular factors in osteoporosis

…, A Juby, D Hanley, W Tymchak… - The Journals of …, 2003 - academic.oup.com
Osteoporosis is a silent epidemic in the world today. With the increase in the elderly population,
there will be an increase in the prevalence of osteoporosis, and so the need for focused …