Mammalian microRNAs (miRNAs) pair to 3′UTRs of mRNAs to direct their posttranscriptional
repression. Important for target recognition are ∼7 nt sites that match the seed region of …

Thousands of mammalian messenger RNAs are under selective pressure to maintain 7-nucleotide
sites matching microRNAs (miRNAs). We found that these conserved targets are …

MicroRNAs (miRNAs) are crucial for normal embryonic stem (ES) cell self-renewal and
cellular differentiation, but how miRNA gene expression is controlled by the key transcriptional …

MicroRNAs (miRNAs) are small regulatory RNAs that derive from distinctive hairpin transcripts.
To learn more about the miRNAs of mammals, we sequenced 60 million small RNAs from …

The RNA world hypothesis regarding the early evolution of life relies on the premise that some
RNA sequences can catalyze RNA replication. In support of this conjecture, we describe …

MicroRNA (miRNA) genes give rise to small regulatory RNAs in a wide variety of organisms.
We used computational methods to predict miRNAs conserved among Drosophila species …

Background and Methods Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease
that causes gradual paralysis, respiratory failure, and death, usually within three to five years …

Objectives: 1) To determine the prevalence of pain, suffering, poor quality of life, depression,
and hopelessness in people with ALS, and the correlates of suffering and poor quality of life…

This study investigated the effect of the emotional content of television news programmes
on mood state and the catastrophizing of personal worries. Three groups were shown 14‐min …

MicroRNAs (miRNAs) regulate numerous biological processes by base-pairing with target
messenger RNAs (mRNAs), primarily through sites in 3′ untranslated regions (UTRs), to …