Two to 11% of women diagnosed with breast cancer will develop contralateral breast cancer
in their lifetime. Women with a first primary are at a 2–6-fold increased risk of developing …

Human organoid systems recapitulate in vivo organ architecture yet fail to capture complex
pathologies such as inflammation and fibrosis. Here, using 11 different healthy and diseased …

Background & Aims Preclinical identification of compounds at risk of causing drug induced
liver injury (DILI) remains a significant challenge in drug development, highlighting a need for …

Organogenesis is a complex and interconnected process that is orchestrated by multiple
boundary tissue interactions 1 , 2 , 3 , 4 , 5 , 6 – 7 . However, it remains unclear how individual, …

The chemokines CCL2 and CCL7 are upregulated in the brain during several neurodegenerative
and acute diseases associated with infiltration of peripheral leukocytes. Astrocytes can …

Background Irreversible pulpitis, which is characterised by acute and intense pain, is one of
the most frequent reasons that patients attend for emergency dental care. Apart from …

Genotype-phenotype associations for common diseases are often compounded by pleiotropy
and metabolic state. Here, we devised a pooled human organoid-panel of steatohepatitis …

Inflammation is the body's defense mechanism against threats such as bacterial infection,
undesirable substances, injury, or illness. The process is complex and involves a variety of …

The Canadian 24-Hour Movement Guidelines for Children and Youth were released in 2016.
These guidelines contained recommendations for moderate to vigorous physical activity, …

Background Historical changes in the nature of sedentary activities have been observed in
other countries, but it is not clear if similar trends exist in Canada. It is also unclear how …