Following the new ESPEN Standard Operating Procedures, the previous guidelines to
provide best medical nutritional therapy to critically ill patients have been updated. These …

Background Supplemental oxygen is often administered liberally to acutely ill adults, but the
credibility of the evidence for this practice is unclear. We systematically reviewed the …

BACKGROUND: The coronavirus disease 2019 pandemic continues to affect millions worldwide.
Given the rapidly growing evidence base, we implemented a living guideline model to …

Importance Little is known about the relationship between perioperative high-sensitivity
troponin T (hsTnT) measurements and 30-day mortality and myocardial injury after noncardiac …

Importance The effects of recruitment maneuvers and positive end-expiratory pressure (PEEP)
titration on clinical outcomes in patients with acute respiratory distress syndrome (ARDS) …

Background More effective and safer treatments are needed for antineutrophil cytoplasmic
antibody (ANCA)–associated vasculitis. Methods We conducted a randomized trial with a 2-by…

Background Perioperative bleeding is common in patients undergoing noncardiac surgery.
Tranexamic acid is an antifibrinolytic drug that may safely decrease such bleeding. Methods …

The prevalence of asthma continues to increase and its optimal treatment remains a challenge.
Here, we investigated the actions of lipoxin A 4 (LXA 4 ) and its leukocyte receptor in …

Purpose Very old critical ill patients are a rapid expanding group in the ICU. Indications for
admission, triage criteria and level of care are frequently discussed for such patients. However…

Background: Fluid resuscitation is the cornerstone of sepsis treatment. However, whether
balanced or unbalanced crystalloids or natural or synthetic colloids confer a survival …