A biomarker may provide a diagnosis, assess disease severity or risk, or guide other clinical
interventions such as the use of drugs. Although considerable progress has been made in …

Objectives : The objective of this study was to determine whether measuring post-operative
B-type natriuretic peptides (NPs) (ie, B-type natriuretic peptide [BNP] and N-terminal …

OBJECTIVE: With more than 220 million major surgical procedures performed annually,
perioperative interventions leading to even minor mortality reductions would save thousands of …

Continuous predictors are routinely encountered when developing a prognostic model.
Investigators, who are often non‐statisticians, must decide how to handle continuous predictors …

Introduction Dynamic predictors of fluid responsiveness have made automated management
of fluid resuscitation more practical. We present initial simulation data for a novel closed-…

Background Tight perioperative control of blood glucose improves the outcome of diabetic
patients undergoing cardiac surgery. Because stress response and cardiopulmonary bypass …

Background There is substantial variability in the perioperative administration of aspirin in
patients undergoing noncardiac surgery, both among patients who are already on an aspirin …

Background Respiratory arterial pulse pressure variations (PPV) are the best predictors of
fluid responsiveness in mechanically ventilated patients during general anesthesia. However, …

Background There is a need to increase access to surgical treatments in African countries,
but perioperative complications represent a major global health-care burden. There are few …

Background Marked activation of the sympathetic nervous system occurs during and after
noncardiac surgery. Low-dose clonidine, which blunts central sympathetic outflow, may …