Background: As the increasing prevalence of type 2 diabetes mellitus has put pressure on
health systems to appropriately manage these patients, there have been a growing number of …

Background Mediation analysis tests whether the relationship between two variables is
explained by a third intermediate variable. We sought to describe the usage and reporting of …

Importance Clinical guidelines advise against routine electrocardiograms (ECG) in low-risk,
asymptomatic patients, but the frequency and impact of such ECGs are unknown. Objective …

Background Study results vary on whether depressive symptoms are associated with worse
prognosis for low back pain (LBP). We assessed the association between depressive …

Objective To test a scalable health system intervention to improve long term adherence to
secondary prevention treatments among patients who have had a recent myocardial infarction. …

Background : Appropriate use criteria (AUC) have defined transthoracic echocardiogram (TTE)
indications for which there is a clear lack of benefit as rarely appropriate (rA). Objectives : …

Importance Evidence comparing the consequences of Choosing Wisely recommendations
across health systems or with the consequences of recommendations plus policy change is …

Importance The association of low-value testing with downstream care and clinical outcomes
among primary care outpatients is unknown to date. Objective To assess the association of …

Importance International nephrology societies advise against nonsteroidal anti-inflammatory
drug (NSAID) use in patients with hypertension, heart failure, or chronic kidney disease (…

Background Through the Choosing Wisely Canada (CWC) campaign, national medical
specialty societies have released hundreds of recommendations against health care services …