Proton-pump inhibitors: understanding the complications and risks

P Malfertheiner, A Kandulski, M Venerito - … Reviews Gastroenterology & …, 2017 - nature.com
Proton-pump inhibitors (PPIs) are the most effective therapy for the full spectrum of gastric-
acid-related diseases. However, in the past decade, a steadily increasing list of …

Proton pump inhibitors: review of emerging concerns

AK Nehra, JA Alexander, CG Loftus, V Nehra - Mayo Clinic Proceedings, 2018 - Elsevier
First introduced in 1989, proton pump inhibitors (PPIs) are among the most widely utilized
medications worldwide, both in the ambulatory and inpatient clinical settings. The PPIs are …

Proton pump inhibitor use and the risk of chronic kidney disease

B Lazarus, Y Chen, FP Wilson, Y Sang… - JAMA internal …, 2016 - jamanetwork.com
Importance Proton pump inhibitors (PPIs) are among the most commonly used drugs
worldwide and have been linked to acute interstitial nephritis. Less is known about the …

Proton pump inhibitors and risk of incident CKD and progression to ESRD

Y Xie, B Bowe, T Li, H Xian… - Journal of the …, 2016 - journals.lww.com
The association between proton pump inhibitors (PPI) use and risk of acute interstitial
nephritis has been described. However, whether exposure to PPI associates with incident …

Proton pump inhibitors: from CYP2C19 pharmacogenetics to precision medicine

N El Rouby, JJ Lima, JA Johnson - Expert opinion on drug …, 2018 - Taylor & Francis
ABSTRACT Introduction: Proton Pump inhibitors (PPIs) are commonly used for a variety of
acid related disorders. Despite the overall effectiveness and safety profile of PPIs, some …

[HTML][HTML] Risk of death among users of proton pump inhibitors: a longitudinal observational cohort study of United States veterans

Y Xie, B Bowe, T Li, H Xian, Y Yan, Z Al-Aly - BMJ open, 2017 - bmjopen.bmj.com
Objective Proton pump inhibitors (PPIs) are widely used, and their use is associated with
increased risk of adverse events. However, whether PPI use is associated with excess risk of …

Adverse effects of proton-pump inhibitor use in older adults: a review of the evidence

ML Maes, DR Fixen… - Therapeutic advances in …, 2017 - journals.sagepub.com
Proton-pump inhibitors (PPIs) are a widely prescribed class of medications used to treat acid-
related disorders and use has significantly increased over the last few decades. PPIs are …

[HTML][HTML] Potentially inadequate medications in the elderly: PRISCUS 2.0: first update of the PRISCUS list

NK Mann, T Mathes, A Sönnichsen… - Deutsches Ärzteblatt …, 2023 - ncbi.nlm.nih.gov
Background The term potentially inadequate medication (PIM) is used to describe
substances that may be unsuitable for use in the elderly and should be avoided. The …

[HTML][HTML] Proton pump inhibitor use: systematic review of global trends and practices

LGT Shanika, A Reynolds, S Pattison… - European Journal of …, 2023 - Springer
Abstract Purpose Proton pump inhibitors (PPIs) reduce acid secretion in the stomach and
rank as one of the most widely used acid-suppressing medicines globally. While PPIs are …

Proton pump inhibitors: risks of long‐term use

LH Eusebi, S Rabitti, ML Artesiani… - Journal of …, 2017 - Wiley Online Library
Proton pump inhibitors are among the most commonly prescribed classes of drugs, and their
use is increasing, in particular for long‐term treatment, often being over‐prescribed and …