Proton pump inhibitors (PPIs) are among the most frequently prescribed drugs. Even if PPI
are usually considered as safe, there is a growing concern for a range of adverse effects of …

Abstract Purpose The US Food and Drug Administration (FDA) issued three safety
announcements between January 2009 and October 2010 warning against concomitant use …

Background: Prior studies have reported controversial conclusions regarding the risk of
adverse cardiovascular events in patients using proton-pump inhibitors (PPIs) combined …

Background In 2009 and 2010 medicines regulatory agencies published official safety
statements regarding the concomitant use of proton pump inhibitors and clopidogrel. We …

Background: Antisecretory drugs are commonly prescribed with clopidogrel-based dual
antiplatelet therapy (DAPT) to prevent gastrointestinal bleeding in high-risk patients after …

Proton pump inhibitors (PPIs) are among the most frequently prescribed drugs. Even if PPI
are usually considered as safe, there is a growing concern for a range of adverse effects of …

Second, the potential explanation for an apparent association between PPI and ischemic
stroke is channeling bias. Channeling bias refers to the tendency of clinicians to prescribe …

Background In 2009 and 2010 medicines regulatory agencies published official safety
statements regarding the concomitant use of proton pump inhibitors and clopidogrel. We …

Objective While some studies have evaluated the prescribing patterns of clopidogrel in
combination with proton-pump inhibitors (PPI) before and after the FDA safety …

To the Editor: We read with interest the article by Yen-Feng Wang et al.(1), who found that
proton-pump inhibitor (PPI) use is associated with an increased risk of first-time ischemic …