Background: Diabetes often causes kidney disease. In this study, we sought to evaluate if
metformin use was associated with death or kidney events in patients with diabetes and …

Importance Before 2016, safety concerns limited metformin use in patients with kidney
disease; however, the effectiveness of metformin on clinical outcomes in patients with …

Background For patients with type 2 diabetes and chronic kidney disease (CKD), high-
quality evidence about the relative benefits and harms of oral glucose-lowering drugs is …

Background Metformin is recommended as a first-line treatment for patients with type 2
diabetes. However, use of this drug has been contraindicated in individuals with impaired …

Objective To compare the safety of metformin vs sulfonylureas in patients with type 2
diabetes by chronic kidney disease (CKD) stage. Patients and Methods This retrospective …

Results There were 1989 patients on metformin and insulin and 7956 patients on metformin
and sulfonylurea. Median patient age was 60 years old (interquartile range, 54–67), median …

Background Current labelling advises discontinuation of metformin when estimated
glomerular filtration rate (eGFR)< 30 ml/min/1.73 m 2 due to increased risk of lactic acidosis …

Background Metformin has recently been shown not to increase the risk of lactic acidosis in
patients with chronic kidney disease (CKD). Thus, the criteria for metformin use in this …

Aims Metformin could have benefits on cardiovascular disease and kidney disease
progression but is often withheld from individuals with diabetes and chronic kidney disease …

Metformin is the primary treatment for type 2 diabetes mellitus (T2DM) due to its
effectiveness in improving clinical outcomes in patients with preserved renal function …