Background Mitochondrial disorders are clinical syndromes associated with mutations in the
mitochondrial or nuclear genome that result in impaired oxidative phosphorylation and …

There is increasing recognition that mitochondrial dysfunction may have a critical role in the
pathophysiology of major psychiatric illnesses. Patients with mitochondrial disorders offer a …

Aims Accumulated evidence indicates that cerebral metabolic features, evaluated by proton
magnetic resonance spectroscopy (1H‐MRS), are sensitive to early mitochondrion …

Mutations in either nuclear DNA or mitochondrial DNA can result in disruption of oxidative
phosphorylation and lead to mitochondrial dysfunction. Mitochondrial disease …

Introduction Mitochondrial diseases are a common group of genetic neurometabolic
disorders characterised by heterogeneous clinical features including myopathy, auditory …

Purpose Mitochondrial encephalopathy (ME) is a rare disorder of energy metabolism. The
disease course can roughly be evaluated by clinical findings. The purpose of this study was …

Mitochondria are intracellular organelles crucial in the production of cellular energy.
Mitochondrial diseases may result from malfunctions in this biochemical cascade. Several …

MRI and 1H magnetic resonance spectroscopy (1HMRS) are the main neuroimaging
methods to study mitochondrial diseases. MRI can demonstrate seven 'elementary'central …

Psychiatric disorders represent a large class of medical disorders with unclear etiologies
and limited effective treatments. Mitochondrial dysfunction is particularly interesting as it can …

BackgroundMitochondrial dysfunction has been increasingly examined as a potential
pathogenic event in psychiatric disorders, although its role early in the course of major …