RT Journal Article SR Electronic T1 A regional massive hemorrhage protocol developed through a modified Delphi technique JF CMAJ Open JO CMAJ FD Canadian Medical Association SP E546 OP E561 DO 10.9778/cmajo.20190042 VO 7 IS 3 A1 Callum, Jeannie L. A1 Yeh, Calvin H. A1 Petrosoniak, Andrew A1 McVey, Mark J. A1 Cope, Stephanie A1 Thompson, Troy A1 Chin, Victoria A1 Karkouti, Keyvan A1 Nathens, Avery B. A1 Murto, Kimmo A1 Beno, Suzanne A1 Pendergrast, Jacob A1 McDonald, Andrew A1 MacDonald, Russell A1 Adhikari, Neill K.J. A1 Alam, Asim A1 Arnold, Donald A1 Barratt, Lee A1 Beckett, Andrew A1 Brenneman, Sue A1 Chaudhry, Hina Razzaq A1 Collins, Allison A1 Harvey, Margaret A1 Lampron, Jacinthe A1 Margarido, Clarita A1 McFarlan, Amanda A1 Nascimento, Barto A1 Owens, Wendy A1 Pai, Menaka A1 Rizoli, Sandro A1 Ruijs, Theodora A1 Skeate, Robert A1 Skelton, Teresa A1 Sholzberg, Michelle A1 Syer, Kelly A1 Viveiros, Jami-Lynn A1 Theriault, Josee A1 Tinmouth, Alan A1 Van Heest, Rardi A1 White, Susan A1 Zeller, Michelle A1 Pavenski, Katerina YR 2019 UL http://www.cmajopen.ca/content/7/3/E546.abstract AB Background: A massive hemorrhage protocol (MHP) enables rapid delivery of blood components in a patient who is exsanguinating pending definitive hemorrhage control, but there is variability in MHP implementation rates, content and compliance owing to challenges presented by infrequent activation, variable team performance and patient acuity. The goal of this project was to identify the key evidence-based principles and quality indicators required to develop a standardized regional MHP.Methods: A modified Delphi consensus technique was performed in the spring and summer of 2018. Panellists used survey links to independently review and rate (on a 7-point Likert scale) 43 statements and 8 quality indicators drafted by a steering committee composed of transfusion medicine specialists and technologists, and trauma physicians. External stakeholder input from all hospitals in Ontario was sought.Results: Three rounds were held with 36 experts from diverse clinical backgrounds. Consensus was reached for 42 statements and 8 quality indicators. Additional modifications from external stakeholders were incorporated to form the foundation for the proposed MHP.Interpretation: This MHP template will provide the basis for the design of an MHP toolkit, including specific recommendations for pediatric and obstetrical patients, and for hospitals with limited availability of blood components or means to achieve definitive hemorrhage control. We believe that harmonization of MHPs in our region will simplify training, increase uptake of evidence-based interventions, enhance communication, improve patient comfort and safety, and, ultimately, improve patient outcomes.