Grading of Recommendations Assessment, Development and Evaluation evidence profile for primary outcomes
Outcome, no. of studies | Quality assessment | Quality | Importance | |||||
---|---|---|---|---|---|---|---|---|
Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | |||
Illicit opioid use, 7 | Observational studies | Serious* | Very serious†‡ | Not serious | Very serious§ | None | ⊕○○○ VERY LOW | CRITICAL |
Retention, 4 | Observational studies | Not serious | Serious† | Not serious | Very serious§ | None | ⊕○○○ VERY LOW | CRITICAL |