Efficacy and cost variables for antithrombotic medications compared to warfarin
| Medication | Event; OR (95% CI) | Cost per month, $* | ||
|---|---|---|---|---|
| Any bleed | Any stroke | Death | ||
| Acetylsalicylic acid (9) | 0.59 (0.45 to 0.77) | 1.88 (1.40 to 2.51) | 1.04 (0.88 to 1.33) | 1.02 |
| Apixaban (9) | 0.67 (0.60 to 0.75) | 0.79 (0.66 to 0.94) | 0.88 (0.79 to 0.98) | 98.02 |
| Dabigatran, 150 mg (9) | 1.56 (0.50 to 5.74) | 0.65 (0.52 to 0.81) | 0.88 (0.77 to 1.01) | 100.32 |
| Dabigatran, 110 mg (9) | 0.80 (0.69 to 0.93) | 0.90 (0.74 to 1.10) | 0.91 (0.80 to 1.04) | 100.32 |
| Edoxaban, 60 mg (9) | 0.84 (0.77 to 0.90) | 0.86 (0.74 to 1.01) | 0.86 (0.82 to 1.01) | 85.20 |
| Edoxaban, 30 mg (9) | 0.59 (0.54 to 0.64) | 1.13 (0.97 to 1.32) | 0.86 (0.78 to 0.96) | 85.20 |
| Rivaroxaban (9) | 1.03 (0.95 to 1.11) | 0.88 (0.74 to 1.03) | 0.83 (0.69 to 1.00) | 86.10 |
| Warfarin | 1.00 | 1.00 | 1.00 | 39.45‡ |
| Off medication† | 0.77 (0.34 to 1.20) | 1.47 (1.29 to 1.65) | 3.03 (2.79 to 3.27) | – |