Background The available drugs to treat neuropathic pain have incomplete efficacy and
dose-limiting adverse effects. We compared the efficacy of a combination of gabapentin and …

Background Drugs for neuropathic pain have incomplete efficacy and dose-limiting side-effects
when given as monotherapy. We assessed the efficacy and tolerability of combined …

Background Pregnant women with type 1 diabetes are a high-risk population who are
recommended to strive for optimal glucose control, but neonatal outcomes attributed to maternal …

Background: Recent reports from North America and Europe have documented an annual
increase in the incidence of differentiated thyroid carcinoma. We sought to investigate the …

Recent years have seen a steady decline in the number of new physician-investigators (Association
of American Medical Colleges, 2000). To encourage medical students to select …

Background Although metformin is increasingly being used in women with type 2 diabetes
during pregnancy, little data exist on the benefits and harms of metformin use on pregnancy …

Background Type 1 diabetes is characterised by progressive loss of functional β-cell mass,
necessitating insulin treatment. We aimed to investigate the hypothesis that combining anti-…

Background Amiodarone-induced thyrotoxicosis (AIT) develops in 3% of amiodarone-treated
patients in North America. AIT is classified as type 1 or type 2. Type 1 AIT occurs in patients …

Objective To provide updated, evidence-based recommendations for the management of
hypertension in adults. Options and outcomes For lifestyle and pharmacological interventions, …

The Canadian Diabetes Association Clinical Practice Guidelines (CPGs) for the Prevention
and Management of Diabetes in Canada are formally updated in a 5-year cycle in order to …