Background Prescription opioid use is highly associated with risk of opioid-related death,
with 1 of every 550 chronic opioid users dying within approximately 2.5 years of their first …

Background The risk of sexual HIV transmission in serodiscordant couples when the HIV-positive
partner has full virologic suppression on combination antiretroviral therapy (cART) is …

Objective We sought to validate a case-finding algorithm for human immunodeficiency virus
(HIV) infection using administrative health databases in Ontario, Canada. Methods We …

Background Adherence to prescribed regimens is required to derive maximal benefit from
many highly active antiretroviral therapy (HAART) regimens in people living with HIV/AIDS. …

Background Proton pump inhibitors (PPIs) cause interstitial nephritis and are an underappreciated
cause of acute kidney injury. We examined the risk of acute kidney injury and acute …

Background: Pregabalin is an anticonvulsant that is increasingly being prescribed as an
adjunct for chronic pain (1, 2). However, it can be sedating and may augment central nervous …

OBJECTIVE: To summarize existing data regarding potential interactions between recreational
drugs and drugs commonly used in the management of HIV-positive patients. DATA …

Background Trimethoprim therapy can cause hyperkalemia and is often coprescribed with
angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs). …

Objective To determine whether the prescription of co-trimoxazole with an angiotensin
converting enzyme inhibitor or angiotensin receptor blocker is associated with sudden death. …

Aims To characterize the impacts of policies intended to improve opioid prescribing and
prevent opioid-related overdose and death on individuals who take opioids. Methods We …