de Jager et al.26 | N = 271 Intervention: n =138 Control: n = 133 | Daily dose of TrioBe Plus W containing folic acid (0.8 mg), cyanocobalamin (0.5 mg) and pyridoxine HCl (20 mg) for 24 mo | Immediate postintervention |
Doody et al.24 | N = 821 Intervention: n = 409 Control: n = 41 | Donepezil (5 mg/day for 6 wk, 10 mg/day for 42 wk); total duration of interview was 48 wk | Immediate postintervention |
Feldman et al.16 | N = 1018 Intervention: n = 508 Control: n = 510 | Rivastigmine (3-12 mg daily) for up to 48 mo | Immediate postintervention |
Lee et al.22 | N = 36 Intervention: n = 18 Control: n = 18 | Three 1-g soft gelatine capsules each day, each containing docosahexaenoic acid (DHA, 430 mg) and eicosapentaenoic acid (EPA, 150 mg); total dosage for the fish oil group was about 1.3 g DHA and 0.45 mg EPA daily for 12 mo | Immediate postintervention |
Naeini et al.23 | N = 256 Intervention: n = 127 Control: n = 129 | Vitamin E (300 mg daily) plus vitamin C (400 mg daily) for 12 mo | Immediate postintervention |
Petersen et al.27 | N=769 Intervention 1: n = 253 Intervention 2: n = 257 Control: n = 259 | Intervention 1 (donepezil, placebo Vitamin E and multivitamin): initial dose of 5 mg daily; increased to 10 mg daily after 6 wk for 36 mo Intervention 2 (vitamin E, placebo donepezil, multivitamin): initial dose of vitamin E of 1000 IU daily; increased to 2000 IU daily after 6 wk for 36 mo | Immediate postintervention |
Rojas et al.21 | N = 46 Intervention: n = 24 Control: n = 22 | Cognitive stimulation training sessions and cognitive training delivered by two experienced neurophysiologists in 2 weekly group (4-5 participants) sessions of 120 min at hospital-based outpatient memory clinics over 6 mo | 6 mo |
Suzuki et al.18 | N = 50 Intervention: n = 25 Control: n = 25 | Multicomponent exercise group under the supervision of physiotherapists for 90 min/d, 2 d/wk, for a total of 80 times over 12 mo | Immediate postintervention |
Suzuki et al.25 | N = 100 Intervention: n = 50 Control: n = 50 | Six-month, multicomponent exercise program including biweekly 90-min sessions involving aerobic exercise, muscle strength training, postural balance retraining, and dual-task training, and focus on promoting exercise and behaviour change | Immediate postintervention |
Tsolaki et al.19 | N = 196 Intervention: n =1 22 Control: n = 79 | Therapeutic Techniques of nPhTh: holistic approach including cognitive training, cognitive stimulation and psychotherapeutic techniques for 6 mo | Immediate postintervention |
Wei et al.20 | N = 60 Intervention: n = 30 Control: n = 30 | Two groups (15 participants per group) exercised under the supervision of trained nurses for 30 min/d, 5 d/wk, for a total of 120 times over 6 mo | Immediate postintervention |
Winblad et al.17 | Study 1: N = 990 Intervention: n = 494 Control: n = 496 Study 2: N = 1058 Intervention: n = 532 Control: n = 526 | Galantamine was administered at 4 mg twice daily for 1 mo, then 8 mg twice daily for 1 mo; If well-tolerated, the dosage would be titrated to 12 mg twice daily but would be lowered back to 8 mg twice daily after 1 mo if necessary; the dosage selected at month 3 (8 or 12 mg twice daily) was fixed for the remainder of the 24-mo study | Immediate postintervention |