Article Figures & Tables
Tables
- Table 1: Characteristics of 173 women undergoing in vitro fertilization, by vitamin D status
Characteristic Vitamin D status, mean (± SD)* Insufficient or deficient
n = 95Sufficient
n = 78p value† 25-Hydroxy-vitamin D, nmol/L 54.5 ± 14.0 95.5 ± 17.8 < 0.001 Age, yr 34.6 ± 4.0 34.4 ± 3.9 0.8 Ethnic background, no. (%) 0.3 White 56 (58.9) 58 (74.4) Black 3 (3.2) 1 (1.3) Other 36 (37.9) 19 (24.4) Body mass index 24.8 ± 4.7 23.3 ± 3.8 0.02 Gravidity 0.8 ± 1.1 0.9 ± 1.3 0.6 Parity 0.2 ± 0.5 0.3 ± 0.6 0.5 Duration of infertility, mo 20.7 ± 15.1 17.5 ± 12.3 0.1 Follicle-stimulating hormone, baseline, IU/L 6.4 ± 1.9 6.8 ± 2.3 0.9 Antral follicle count, baseline, no. of follicles 15.9 ± 8.4 17.7 ± 10.3 0.2 Previous IVF cycles, no. 0.7 ± 1.0 0.6 ± 1.0 0.4 Season in which IVF cycle was performed, no. (%) of patients 0.8 Spring 50 (52.6) 41 (52.6) Summer 31 (32.6) 28 (35.9) Fall 14 (14.7) 9 (11.5) Note: IVF = in vitro fertilization, SD = standard deviation. *Unless otherwise stated. †χ2 (categorical) and Student t or Mann–Whitney U (continuous) test; statistically significant, p < 0.05.
Characteristic Vitamin D status, no. (%) or mean ± SD p value* Insufficient or deficient
n = 95Sufficient
n = 78IVF protocol, no. (%) 0.08 Long 29 (30.5) 34 (43.6) Antagonist 64 (67.4) 40 (51.3) Flare 2 (2.1) 4 (5.1) Day of hCG injection 12.1 ± 1.3 11.9 ± 1.4 0.4 Gonadotropin dose, IU 2602.8 ± 1287.3 2547.1 ± 1330.3 0.8 Follicle diameter > 14 mm, no. 11.9 ± 6.5 11.7 ± 5.8 0.8 Estradiol level on the day of hCG administration, pmol/L 8556.7 ± 6187.3 9776.15 ± 5902.6 0.2 Endometrial thickness on the day of hCG administration, cm 1.0 ± 1.6 1.0 ± 0.2 0.5 Oocytes retrieved, no. 12.6 ± 7.4 12.7 ± 6.6 0.9 Intracytoplasmic sperm injection, no. (%) 74 (77.9) 63 (80.8) 0.4 Embryos transferred, no. 1.8 ± 1.0 1.8 ± 0.9 0.9 Day of embryo transfer, no. (%) Day 3 31 (32.6) 19 (24.4) 0.2 Day 5 56 (58.9) 56 (71.8) 0.054.00 Implantation rate, % 25.6 34.5 0.6 Clinical pregnancy rate, per cycle start, % 34.7 52.5 < 0.001 Clinical pregnancy rate, per embryo transfer, % 37.9 54.7 < 0.001 Note: hCG = human chorionic gonadotropin, SD = standard deviation. *χ2 (categorical) and Students t or Mann–Whitney U (continuous) test; statistically significant, p < 0.05. †Follicle-stimulating hormone or human menopausal gonadotropin, depending on protocol.
- Table 3: Predictors of clinical pregnancy among 173 women undergoing in vitro fertilization
Variable Crude OR (95% CI) p value Adjusted OR (95% CI)* p value† Age, yr 0.96 (0.89–1.04) 0.3 0.98 (0.90–1.07) 0.7 Body mass index 0.92 (0.86–1.00) 0.05 0.94 (0.87–1.01) 0.1 Day 5 embryos transferred (v. day 3) 1.50 (0.81–2.90) 0.2 1.28 (0.61–2.77) 0.5 25-Hydroxy-vitamin D, mmol/L 1.02 (1.00–1.03) 0.2 1.01 (1.00–1.03) 0.05 Note: CI = confidence interval, OR = odds ratio. *Analyses adjusted for age, BMI, number of day 5 embryos transferred and 25 OH-D level. †Statistically significant, p < 0.05.