Whole population, 1984–2015 |
|
Sex, female | 27 663 (54.6) | 5536 (54.6) | 21 564 (70.3) | 4322 (70.2) | 61 231 (72.2) | 12 263 (72.2) | 109 065 (66.4) | 21 841 (66.4) |
|
Age at diagnosis, yr, mean ± SD (range) | 41.7 ± 17.0 (18 to 99) | 41.7 ± 17.0 (18 to 99) | 42.1 ± 13.5 (18 to 97) | 42.1 ± 13.5 (18 to 96) | 54.0 ± 16.1 (18 to 105) | 54.0 ± 16.1 (18 to 103) | 48.0 ± 17.1 (18 to 105) | 48.0 ± 17.1 (18 to 103) |
|
Duration of follow-up from index date, yr, median (IQR) | 11.9 (4.92 to 21.8) | 13.3 (5.93 to 22.8) | 13.9 (5.91 to 23.6) | 13.9 (6.28 to 22.5) | 11.1 (4.93 to 19.3) | 11.4 (5.51 to 19.0) | 11.9 (5.12 to 20.8) | 12.4 (5.79 to 20.7) |
|
Urban region of residence | 33 799 (66.7) | 6763 (66.6) | 20 685 (67.4) | 4154 (67.5) | 50 281 (59.3) | 10 070 (59.3) | 103 468 (63.0) | 20 727 (63.0) |
|
Socioeconomic status,‡§ mean ± SD | −0.23 ± 0.88 | −0.26 ± 0.91 | −0.22 ± 0.88 | −0.25 ± 0.91 | 0.06 ± 1.01 | 0.03 ± 1.03 | −0.08 ± 0.96 | −0.11 ± 0.99 |
|
Physician visits in prior year |
|
0–4 | 41 688 (82.2) | 6569 (64.7) | 24 637 (80.3) | 3860 (62.7) | 63 997 (75.5) | 8416 (45.6) | 128 760 (78.4) | 19 997 (60.8) |
|
5–9 | 6517 (12.9) | 2172 (21.4) | 4196 (13.7) | 1313 (21.3) | 14 230 (16.8) | 3718 (21.9) | 24 623 (15.0) | 7297 (22.2) |
|
≥ 10 | 2499 (4.9) | 1407 (13.9) | 1857 (6.0) | 985 (16.0) | 6529 (7.7) | 4841 (28.5) | 10 769 (6.6) | 5586 (17.0) |
|
Comorbidity status at study start |
|
No. of ADGs |
|
0 | 42 318 (83.5) | 6749 (66.5) | 26 373 (85.9) | 4389 (71.3) | 65 883 (77.7) | 11 216 (66.1) | 133 038 (81.0) | 22 275 (67.7) |
|
1 | 7246 (14.3) | 2789 (27.5) | 3763 (12.3) | 1392 (22.6) | 15 605 (18.4) | 4643 (27.4) | 26 227 (16.0) | 8561 (26.0) |
|
≥ 2 | 1140 (2.2) | 610 (6.0) | 554 (1.8) | 377 (6.1) | 3268 (3.9) | 1116 (6.6) | 4887 (3.0) | 2044 (6.2) |
|
Any mood or anxiety disorder | 10 979 (21.7) | 3147 (31.0) | 7431 (24.2) | 2485 (40.4) | 22 078 (26.0) | 5735 (33.8) | 39 911 (24.3) | 11 171 (34.0) |
|
Depression | 9590 (18.9) | 2764 (27.2) | 6546 (21.3) | 2197 (35.7) | 18 853 (22.2) | 4864 (28.7) | 34 480 (21.0) | 9645 (29.3) |
|
Anxiety disorder | 13 438 (26.5) | 3453 (34.0) | 8931 (29.1) | 2378 (38.6) | 25 922 (30.6) | 6074 (35.8) | 47 639 (29.0) | 11 707 (35.6) |
|
Bipolar disorder | 1562 (3.1) | 548 (5.4) | 1151 (3.8) | 368 (6.0) | 2963 (3.5) | 716 (4.2) | 5583 (3.4) | 1602 (4.9) |
|
Population, 2006–2015 | n = 40 364 | n = 8458 | n = 24 154 | n = 4748 | n = 64 510 | n = 12 984 | n = 127 310 | n = 25 832 |
|
Sex, female | 22 207 (55.0) | 4623 (54.7) | 17 247 (71.4) | 3399 (71.6) | 47 102 (73.0) | 9458 (72.8) | 85 349 (67.0) | 8602 (33.3) |
|
Age at diagnosis, yr, mean ± SD (range) | 41.2 ± 16.2 (18 to 99) | 41.0 ± 16.2 (18 to 99) | 40.9 ± 12.2 (18 to 97) | 40.2 ± 11.9 (18 to 94) | 51.8 ± 15.2 (18 to 105) | 51.4 ± 15.4 (18 to 102) | 46.4 ± 16.0 (18 to 105) | 45.9 ± 16.0 (18 to 102) |
|
Urban region of residence | 26 558 (65.8) | 5574 (65.9) | 15 925 (65.9) | 3153 (66.4) | 37 559 (58.2) | 7609 (58.6) | 78 949 (62.0) | 16 104 (62.3) |
|
Socioeconomic status,‡ mean ± SD | −0.22 ± 0.85 | −0.26 ± 0.89 | −0.21 ± 0.85 | −0.25 ± 0.89 | 0.06 ± 1.0 | 0.04 ± 1.0 | −0.08 ± 0.95 | −0.11 ± 0.98 |
|
Physician visits in prior year |
|
0–4 | 26 789 (66.4) | 3810 (45.0) | 15 224 (63.0) | 2260 (47.6) | 37 960 (58.8) | 4745 (36.5) | 78 891 (62.0) | 10 716 (41.5) |
|
5–9 | 8700 (21.6) | 2358 (27.9) | 5711 (23.6) | 1313 (27.7) | 16 064 (24.9) | 3593 (27.7) | 30 072 (23.6) | 7171 (27.8) |
|
≥ 10 | 4875 (12.1) | 2290 (27.1) | 3219 (13.3) | 1175 (24.7) | 10 486 (16.3) | 4646 (35.8) | 18 347 (14.4) | 7945 (30.8) |
|
Comorbidity status at index date |
|
No. of ADGs |
|
0 | 33 895 (84.0) | 5546 (65.6) | 20 903 (86.5) | 3371 (71.0) | 51 284 (79.5) | 8594 (66.2) | 104 753 (82.3) | 17 434 (67.5) |
|
1 | 5638 (14.0) | 2390 (28.2) | 2892 (12.0) | 1089 (22.9) | 11 140 (17.3) | 3577 (27.5) | 19 340 (15.2) | 6827 (26.4) |
|
≥ 2 | 831 (2.0) | 522 (6.2) | 359 (1.5) | 288 (6.1) | 2086 (3.2) | 813 (6.3) | 3217 (2.5) | 1571 (6.1) |
|
Any mood and anxiety disorder | 9108 (22.6) | 2669 (31.6) | 6119 (25.3) | 1985 (41.8) | 17 008 (26.4) | 4490 (34.6) | 31 739 (24.9) | 8960 (34.7) |
|
Depression | 7992 (19.8) | 2343 (27.7) | 5410 (22.4) | 1742 (36.7) | 14 548 (22.6) | 3808 (29.3) | 27 517 (21.6) | 7723 (29.9) |
|
Anxiety disorder | 11 444 (28.4) | 2980 (35.2) | 7543 (31.2) | 1983 (41.8) | 21 332 (33.1) | 5063 (39.0) | 39 735 (31.2) | 9839 (38.1) |
|
Bipolar disorder | 1326 (3.3) | 465 (5.5) | 968 (4.0) | 301 (6.3) | 2347 (3.6) | 575 (4.4) | 4559 (3.6) | 1312 (5.1) |